Back to Search
Start Over
Human C1orf27 protein interacts with α
- Source :
- The Journal of biological chemistry. 298(6)
- Publication Year :
- 2022
-
Abstract
- The molecular mechanisms underlying the anterograde surface transport of G protein-coupled receptors (GPCRs) after their synthesis in the endoplasmic reticulum (ER) are not well defined. In C. elegans, odorant response abnormal 4 has been implicated in the delivery of olfactory GPCRs to the cilia of chemosensory neurons. However, the function and regulation of its human homolog, C1orf27, in GPCR transport or in general membrane trafficking remain unknown. Here, we demonstrate that siRNA-mediated knockdown of C1orf27 markedly impedes the ER-to-Golgi export kinetics of newly synthesized α
Details
- ISSN :
- 1083351X
- Volume :
- 298
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- The Journal of biological chemistry
- Accession number :
- edsair.pmid..........54ac7479323bbbeba397e06c84f09a4f