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Structural and Functional Analysis of the Pyridoxal Phosphate Homeostasis Protein YggS from
- Source :
- Molecules (Basel, Switzerland). 27(15)
- Publication Year :
- 2022
-
Abstract
- Pyridoxal 5'-phosphate (PLP) is the active form of vitamin B6, but it is highly reactive and poisonous in its free form. YggS is a PLP-binding protein found in bacteria and humans that mediates PLP homeostasis by delivering PLP to target enzymes or by performing a protective function. Several biochemical and structural studies of YggS have been reported, but the mechanism by which YggS recognizes PLP has not been fully elucidated. Here, we report a functional and structural analysis of YggS from
Details
- ISSN :
- 14203049
- Volume :
- 27
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Molecules (Basel, Switzerland)
- Accession number :
- edsair.pmid..........576467a64ac22cc930b02f9b8b4a6a68