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[Genetic and environmental factors of asthma and allergy: Results of the EGEA study]
- Source :
- Revue des maladies respiratoires. 32(8)
- Publication Year :
- 2014
-
Abstract
- The EGEA study (epidemiological study on the genetics and environment of asthma, bronchial hyperresponsiveness and atopy), which combines a case-control and a family-based study of asthma case (n=2120 subjects) with three surveys over 20 years, aims to identify environmental and genetic factors associated with asthma and asthma-related phenotypes. We summarize the results of the phenotypic characterization and the investigation of environmental and genetic factors of asthma and asthma-related phenotypes obtained since 2007 in the EGEA study (42 articles).Both epidemiological and genetic results confirm the heterogeneity of asthma. These results strengthen the role of the age of disease onset, the allergic status and the level of disease activity in the identification of the different phenotypes of asthma. The deleterious role of active smoking, exposure to air pollution, occupational asthmogenic agents and cleaning products on the prevalence and/or activity of asthma has been confirmed. Accounting for gene-environment interactions allowed the identification of new genetic factors underlying asthma and asthma-related traits and better understanding of their mode of action.The EGEA study is contributing to the advances in respiratory research at the international level. The new phenotypic, environmental and biological data available in EGEA study will help characterizing the long-term evolution of asthma and the factors associated to this evolution.
- Subjects :
- Adult
Hypersensitivity, Immediate
Male
Adolescent
Polymorphism, Single Nucleotide
Genetic Heterogeneity
Risk Factors
Air Pollution
Occupational Exposure
Humans
Genetic Predisposition to Disease
Child
Genetic Association Studies
Aged
Family Health
Smoking
Environmental Exposure
Middle Aged
Health Surveys
Asthma
Phenotype
Case-Control Studies
Gene-Environment Interaction
Tobacco Smoke Pollution
France
Bronchial Hyperreactivity
Subjects
Details
- Language :
- French
- ISSN :
- 17762588
- Volume :
- 32
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Revue des maladies respiratoires
- Accession number :
- edsair.pmid..........5913ec59b73528e8cd3df7e1e274fc31