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Linitis Plastica: a Distinct Type of Gastric Cancer

Linitis Plastica: a Distinct Type of Gastric Cancer

Authors :
Naruhiko, Ikoma
Annamaria, Agnes
Hsiang-Chun, Chen
Xuemei, Wang
Mariela M, Blum
Prajnan, Das
Bruce, Minsky
Jeannelyn S, Estrella
Paul, Mansfield
Jaffer A, Ajani
Brian D, Badgwell
Source :
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract. 24(5)
Publication Year :
2019

Abstract

The prognosis of patients with linitis plastica (LP) gastric cancer is reported to be poor. The purpose of our retrospective study was to characterize the clinicopathologic features and survival outcomes of patients with LP, using a univocal definition.We defined LP as gastric cancer that involves more than 1/3 of the gastric wall macroscopically. We reviewed a prospectively maintained institutional database of gastric cancer patients and summarized and compared clinicopathologic factors of patients with and without LP who had undergone gastrectomy. Patients were matched 1:1 using propensity score matching, and their overall survival (OS) rates and durations were compared. Multivariable Cox regression analyses were conducted, using gastrectomy as a time-varying covariate.We identified 740 patients with radiographically non-metastatic gastric cancer, 157 (21.2%) of whom had LP. Most patients with LP had advanced-stage disease (75.8% had stage IV disease, mainly due to peritoneal involvement). Patients with LP had significantly shorter OS durations than did those without LP in the entire cohort (median OS, 14.0 vs. 33.5 months; p value0.001) and in the surgical cohort (median OS after gastrectomy, 21.8 vs. 91.0 months; p0.001), as well as in the propensity-matched surgical cohort. In the LP cohort, chemotherapy (hazard ratio [HR] = 0.594; p = 0.076), chemoradiation therapy (HR = 0.346; p = 0.001), and gastrectomy (HR = 0.425; p = 0.003) were associated with a longer OS.LP is a phenotype of gastric cancer that often presents at an advanced stage, with a high rate of peritoneal involvement. The survival durations of patients with LP were poor in our study, even in the surgical cohort. The use of preoperative chemotherapy, chemoradiation therapy, and gastrectomy appeared to be important in carefully selected patients with localized LP.

Details

ISSN :
18734626
Volume :
24
Issue :
5
Database :
OpenAIRE
Journal :
Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract
Accession number :
edsair.pmid..........5ab75c6c01b0f99f91aeb546714fdbe6