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Cell membrane gp96 facilitates HER2 dimerization and serves as a novel target in breast cancer

Authors :
Xin, Li
Lu, Sun
Junwei, Hou
Mingming, Gui
Jianming, Ying
Hong, Zhao
Ning, Lv
Songdong, Meng
Source :
International journal of cancer. 137(3)
Publication Year :
2014

Abstract

HER2 receptor dimerization is a critical step in the HER2 activation process. Here, we demonstrated that heat shock protein gp96 on cell membrane interacts with HER2, facilitates HER2 dimerization and promotes cell proliferation. Cell membrane gp96 levels were observed to correlate with HER2 phosphorylation in primary breast tumors. Finally, we provide evidence that targeting gp96 with a specific monoclonal antibody led to decreased cell growth and increased apoptosis in vitro, and suppression of tumor growth in vivo. Our work represents a new therapeutic strategy for inhibiting HER2 signaling in cancer.

Details

ISSN :
10970215
Volume :
137
Issue :
3
Database :
OpenAIRE
Journal :
International journal of cancer
Accession number :
edsair.pmid..........5b7f8f179f1390a8fb999a0e09f6521c