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Interleukin-8 is a prognostic indicator in human hilar cholangiocarcinoma
- Publication Year :
- 2015
- Publisher :
- e-Century Publishing Corporation, 2015.
-
Abstract
- Interleukin-8 (IL-8), matrix metalloproteinase-9 (MMP-9) and neovascularization have been implicated to be associated with biological processes, especially cancer progression. However, few studies have investigated the role of IL-8 in human hilar cholangiocarcinoma. In this study we detected the expression of IL-8 combined with MMP-9 and microvessel density (MVD) in hilar cholangiocarcinoma to evaluate their clinicopathological significance and prognostic value. A total of 62 patients with hilar cholangiocarcinoma who underwent curative surgery were enrolled in this study. The expression of IL-8, MMP-9 and MVD were examined immunohistochemically. The correlation of IL-8 with MMP-9 expression, MVD, clinicopathological features and survival time of patients were then analyzed. Expression of IL-8 was observed in 56.5% tumors, which was related to advanced TNM stage (P = 0.026) and tumor recurrence (P = 0.018). IL-8 had a positive correlation with MMP-9 expression and MVD. Furthermore, patients with high IL-8 expression had a significantly shorter overall survival than those with low IL-8 expression (P = 0.01). Multivariate analysis confirmed IL-8 as an independent prognostic factor (P = 0.005). In conclusion, IL-8 expression significantly correlated with MMP-9 expression and MVD, and IL-8 was a valuable prognostic factor for human hilar cholangiocarcinoma.
- Subjects :
- Adult
Male
Chi-Square Distribution
Time Factors
Neovascularization, Pathologic
Interleukin-8
Kaplan-Meier Estimate
Middle Aged
Immunohistochemistry
digestive system diseases
Treatment Outcome
Bile Duct Neoplasms
Matrix Metalloproteinase 9
Predictive Value of Tests
Risk Factors
Microvessels
Multivariate Analysis
Biomarkers, Tumor
Humans
Original Article
Female
Aged
Klatskin Tumor
Proportional Hazards Models
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid..........5bfd0d3bf7480a44806d8577a7d597c3