Back to Search
Start Over
Direct control of somatic stem cell proliferation factors by the
Direct control of somatic stem cell proliferation factors by the
- Source :
- Development (Cambridge, England). 145(17)
- Publication Year :
- 2017
-
Abstract
- Niches have traditionally been characterised as signalling microenvironments that allow stem cells to maintain their fate. This definition implicitly assumes that the various niche signals are integrated towards a binary fate decision between stemness and differentiation. However, observations in multiple systems have demonstrated that stem cell properties, such as proliferation and self-renewal, can be uncoupled at the level of niche signalling input, which is incompatible with this simplified view. We have studied the role of the transcriptional regulator Zfh1, a shared target of the Hedgehog and Jak/Stat niche signalling pathways, in the somatic stem cells of the
- Subjects :
- Male
Site-Specific DNA-Methyltransferase (Adenine-Specific)
Stem Cell Factor
Tumor Suppressor Proteins
Nuclear Proteins
Cell Cycle Proteins
YAP-Signaling Proteins
Cell Line
Animals, Genetically Modified
Repressor Proteins
Adult Stem Cells
Testis
Trans-Activators
Animals
Drosophila Proteins
Drosophila
Stem Cell Niche
Cell Proliferation
Protein Binding
Signal Transduction
Subjects
Details
- ISSN :
- 14779129
- Volume :
- 145
- Issue :
- 17
- Database :
- OpenAIRE
- Journal :
- Development (Cambridge, England)
- Accession number :
- edsair.pmid..........5e293e1ce807ac0002b3d26ce3ff5f78