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Direct control of somatic stem cell proliferation factors by the

Direct control of somatic stem cell proliferation factors by the

Authors :
Eugene A, Albert
Olga A, Puretskaia
Nadezhda V, Terekhanova
Anastasia, Labudina
Christian, Bökel
Source :
Development (Cambridge, England). 145(17)
Publication Year :
2017

Abstract

Niches have traditionally been characterised as signalling microenvironments that allow stem cells to maintain their fate. This definition implicitly assumes that the various niche signals are integrated towards a binary fate decision between stemness and differentiation. However, observations in multiple systems have demonstrated that stem cell properties, such as proliferation and self-renewal, can be uncoupled at the level of niche signalling input, which is incompatible with this simplified view. We have studied the role of the transcriptional regulator Zfh1, a shared target of the Hedgehog and Jak/Stat niche signalling pathways, in the somatic stem cells of the

Details

ISSN :
14779129
Volume :
145
Issue :
17
Database :
OpenAIRE
Journal :
Development (Cambridge, England)
Accession number :
edsair.pmid..........5e293e1ce807ac0002b3d26ce3ff5f78