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Biotransformation of (-)-(10E,15S)-10,11-Dehydrocurvularin
- Source :
- Natural product communications. 10(7)
- Publication Year :
- 2015
-
Abstract
- (-)-(10E,15S)-10,11-Dehydrocurvularin (1), produced from an associated-fungus of Scolopendra subspinipes mutilans on a gram scale, was microbiologically converted to curvularin (2) and 5-methoxycurvularin (3) by Antrodiella semisupina in 61% totally isolated yield. The structures of these compounds were elucidated on the basis of spectroscopic and mass spectrometric analysis. The undescribed assignments of 1H and 13C NMR spectral data for 5-methoxycurvularin (2) has now been explicitly provided. The cytotoxic activities of compounds 1-3 against four human cancer cell lines were evaluated. Dehydrocurvularin (1) showed moderate cytotoxicity against Caski and Hep-G2, and curvularin (2) was selectively cytotoxic against MDA-MB-231.
Details
- ISSN :
- 1934578X
- Volume :
- 10
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Natural product communications
- Accession number :
- edsair.pmid..........5f3708b728e4ae3f084c3bdc4e2ce34b