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EGFR-targeted delivery of DOX-loaded Fe

Authors :
Xupeng, Mu
Fuqiang, Zhang
Chenfei, Kong
Hongmei, Zhang
Wenjing, Zhang
Rui, Ge
Yi, Liu
Jinlan, Jiang
Source :
International Journal of Nanomedicine
Publication Year :
2017

Abstract

Multifunctional nanocomposites that have multiple therapeutic functions together with real-time imaging capabilities have attracted intensive concerns in the diagnosis and treatment of cancer. This study developed epidermal growth factor receptor (EGFR) antibody-directed polydopamine-coated Fe3O4 nanoparticles (Fe3O4@PDA NPs) for magnetic resonance imaging and antitumor chemo-photothermal therapy. The synthesized Fe3O4@PDA-PEG-EGFR-DOX NPs revealed high storage capacity for doxorubicin (DOX) and high photothermal conversion efficiency. The cell viability assay of Fe3O4@PDA-PEG-EGFR NPs indicated that Fe3O4@ PDA-PEG-EGFR NPs had no cell cytotoxicity. However, Fe3O4@PDA-PEG-EGFR-DOX NPs could significantly decrease cell viability (~5% of remaining cell viability) because of both photothermal ablation and near-infrared light-triggered DOX release. Meanwhile, the EGFR-targeted Fe3O4@PDA-PEG-EGFR-DOX NPs significantly inhibited the growth of tumors, showing a prominent in vivo synergistic antitumor effect. This study demonstrated the potential of using Fe3O4@PDA NPs for combined cancer chemo-photothermal therapy with increased efficacy.

Details

ISSN :
11782013
Volume :
12
Database :
OpenAIRE
Journal :
International journal of nanomedicine
Accession number :
edsair.pmid..........60d6d2931fc9dced6c30f98ce5b370e7