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An approach to suppress the evolution of resistance in BRAF
- Source :
- Nature medicine. 23(8)
- Publication Year :
- 2017
-
Abstract
- The principles that govern the evolution of tumors exposed to targeted therapy are poorly understood. Here we modeled the selection and propagation of an amplification in the BRAF oncogene (BRAF
- Subjects :
- Adult
Male
Proto-Oncogene Proteins B-raf
Lung Neoplasms
Skin Neoplasms
Adenocarcinoma of Lung
Pemetrexed
Adenocarcinoma
Carboplatin
Mice
Antineoplastic Combined Chemotherapy Protocols
Animals
Humans
Extracellular Signal-Regulated MAP Kinases
Melanoma
Protein Kinase Inhibitors
In Situ Hybridization, Fluorescence
Aged
Mitogen-Activated Protein Kinase Kinases
Middle Aged
Xenograft Model Antitumor Assays
Bevacizumab
Drug Resistance, Neoplasm
Female
raf Kinases
Cisplatin
Single-Cell Analysis
Subjects
Details
- ISSN :
- 1546170X
- Volume :
- 23
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Nature medicine
- Accession number :
- edsair.pmid..........62a7cd2a481f2604947ea961cf83598c