Rapid non-uniform adaptation to conformation-specific KRAS(G12C) inhibition

Authors :: Jenny Y, Xue
Yulei, Zhao
Jordan, Aronowitz
Trang T, Mai
Alberto, Vides
Besnik, Qeriqi
Dongsung, Kim
Chuanchuan, Li
Elisa, de Stanchina
Linas, Mazutis
Davide, Risso
Piro, Lito
Source :: Nature. 577(7790)
Publication Year :: 2019
Abstract: KRAS GTPases are activated in one-third of cancers, and KRAS(G12C) is one of the most common activating alterations in lung adenocarcinoma

Subjects :: ErbB Receptors
Proto-Oncogene Proteins p21(ras)
Lung Neoplasms
Cell Line, Tumor
Mutation
Adaptation, Biological
Humans
Enzyme Inhibitors
Signal Transduction

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