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[Activity of myocardial sympathetic-adrenal system with various volume of viable myocardium in patients with chronic cardiac failure]
- Source :
- Terapevticheskii arkhiv. 76(2)
- Publication Year :
- 2004
-
Abstract
- To estimate sympathetic activity in patients with ischemic heart disease (IHD) complicated by chronic cardiac failure (CCF) depending on the volume of viable myocardium measured by dobutamine stress echocardiography (DSE).Planar myocardial I-231-MIBG scintigraphy and dobutamine stress echocardiography were made in 16 patients (9 males and 7 females) aged 43-75 years with CCF (NYHA class II-III) and ejection fraction under 35%. The ratio maximal MIBG absorption in the left ventricular myocardium to maximal MIBG absorption in the mediastenum (H/M) and lung (H/L) were estimated.By DSE the patients were divided into two groups: responders in whom contractility improved by 4 and more points (9 patients) and non-responders in whom contractility improved by less than 4 scores (7 patients). The groups did not differ by clinical and hemodynamic parameters but group 2 patients had significantly lower H/M and H/L than group 1 patients (1.38 +/- 0.02 and 1.08 +/- 0.06 against 1.61 +/- 0.09 and 1.25 +/- 0.12, respectively, p0.05). A direct correlation was found between MIBG absorption (H/M, H/L) and ejection fraction on minimal dobutamine doses (r = 0.77, p0.01; r = 0.87, p0.001), gain in ejection fraction (r = 0.77, p0.01; r = 0.45, p0.05), and inverse correlation between MIBG absorption (H/M, H/L) and dyssynergia index on minimal dobutamine doses (r = -0.80, p0.001; r = -0.87, p0.0001).Patients with CCF demonstrate a correlation between sympathetic activity and volume of viable myocardium, inotropic reserve.
Details
- ISSN :
- 00403660
- Volume :
- 76
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Terapevticheskii arkhiv
- Accession number :
- edsair.pmid..........6515a57bbeda1ae625476dda847a23a3