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Multicenter Retrospective Analysis of Chemotherapy for Advanced Pancreatic Acinar Cell Carcinoma
- Source :
- Pancreas
- Publication Year :
- 2020
- Publisher :
- Lippincott Williams & Wilkins, 2020.
-
Abstract
- Objectives The aim of this multicenter retrospective study was to identify the optimal chemotherapeutic regimen for advanced pancreatic acinar cell carcinoma (PACC). Methods Fifty-eight patients with histopathologically confirmed advanced PACC who had received chemotherapy between 1996 and 2013 were enrolled. The clinical characteristics of the patients and the treatment efficacy data were collected from the medical records at 16 Japanese institutions, using standardized data collection instrument. Results The most commonly selected treatment regimens were gemcitabine-, fluoropyrimidine-, platinum-, and irinotecan-containing regimens. The overall response rate in the patients who received first-line chemotherapy were 7% and 38%, respectively, and the median overall survival was 13.2 months. When the data for all the treatment lines were aggregated, the response rates to gemcitabine-, fluoropyrimidine-, platinum-, and irinotecan-containing regimens were 7%, 18%, 40%, and 29%, respectively. The overall survival tended to be better in patients who had received a platinum-containing regimen (hazard ratio, 0.50; 95% confidence interval, 0.23–1.11; P = 0.08) or irinotecan-containing regimen (hazard ratio, 0.42; 95% confidence interval, 0.15–1.19; P = 0.09) at least once in the treatment course as compared with those who had not. Conclusions Our findings suggested that platinum- and irinotecan-containing regimens exhibited some potential efficacy in patients with advanced PACC.
- Subjects :
- Aged, 80 and over
Adult
Male
Time Factors
Adolescent
Carcinoma, Acinar Cell
pancreatic neoplasms
Platinum Compounds
Original Articles
Middle Aged
chemotherapy
Irinotecan
Progression-Free Survival
Young Adult
Japan
Antineoplastic Combined Chemotherapy Protocols
Disease Progression
Humans
Female
5-fluorouracil
platinum
Child
acinar cell carcinoma
Aged
Retrospective Studies
Subjects
Details
- Language :
- English
- ISSN :
- 15364828 and 08853177
- Volume :
- 50
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Pancreas
- Accession number :
- edsair.pmid..........659b00e702eff1313b3c720df9c1913d