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Effects of early life stress on cocaine intake in male and female rhesus macaques

Effects of early life stress on cocaine intake in male and female rhesus macaques

Authors :
Alison G P, Wakeford
Brik, Kochoian
Erin R, Siebert
Sarah, Katznelson
Elyse L, Morin
Brittany R, Howell
Kai M, McCormack
Michael A, Nader
Mar M, Sanchez
Leonard L, Howell
Source :
Psychopharmacology. 237(12)
Publication Year :
2019

Abstract

It is critical to identify potential risk factors, such as a history of early life stress (ELS), that may confer specific vulnerabilities to increased drug intake.In this study, we examined whether male and female rhesus monkeys with a history of ELS (infant maltreatment; MALT) demonstrated significantly greater cocaine intake compared with controls.Monkeys were trained to self-administer cocaine during 4-h sessions at a peak dose (0.003-0.1 mg/kg/infusion; extended access, "EA peak") and a dose of 0.1 mg/kg/infusion (EA 0.1) of cocaine. These data were compared with data obtained previously in monkeys trained during 1-h limited access (LA) sessions at the same peak dose of cocaine used here (Wakeford et al. Psychopharmacology, 236:2785-2796, 2019).Monkeys significantly increased total number of infusions earned in EA compared with LA, but total session response rates significantly decreased in EA compared with LA. There was no evidence of escalation in drug intake when we compared response rates to obtain the first 20 cocaine infusions between LA and EA peak conditions. Moreover, there was no evidence of escalation in drug intake during an additional 7 weeks of self-administration at 0.1 mg/kg/injection.The current study expands on previous reports demonstrating that rhesus macaques did not escalate cocaine intake under the experimental conditions employed and extended these findings by using a unique population of nonhuman primates with a history of infant MALT to test the hypothesis that ELS is a risk factor for escalation of cocaine intake in nonhuman primates. There was no clear evidence of escalation in cocaine intake as a consequence of ELS.

Details

ISSN :
14322072
Volume :
237
Issue :
12
Database :
OpenAIRE
Journal :
Psychopharmacology
Accession number :
edsair.pmid..........66d86d775f175ce81742f805b8d6a2da