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Proteasome, a Promising Therapeutic Target for Multiple Diseases Beyond Cancer

Authors :
Yu, Cao
Huajian, Zhu
Ruoyu, He
Limin, Kong
Jiaan, Shao
Rangxiao, Zhuang
Jianjun, Xi
Jiankang, Zhang
Source :
Drug Design, Development and Therapy
Publication Year :
2020

Abstract

Proteasome is vital for intracellular protein homeostasis as it eliminates misfolded and damaged protein. Inhibition of proteasome has been validated as a powerful strategy for anti-cancer therapy, and several drugs have been approved for treatment of multiple myeloma. Recent studies indicate that proteasome has potent therapeutic effects on a variety of diseases besides cancer, including parasite infectious diseases, bacterial/fungal infections diseases, neurodegenerative diseases and autoimmune diseases. In this review, recent developments of proteasome inhibitors for various diseases and related structure activity relationships are going to be summarized.

Details

ISSN :
11778881
Volume :
14
Database :
OpenAIRE
Journal :
Drug design, development and therapy
Accession number :
edsair.pmid..........675553d0bb3c3850ecdcab1a27b90c6c