Association of LPIN1 gene variations with markers of metabolic syndrome in population from Bosnia and Herzegovina

To investigate association of two LPIN1 gene variations with main traits of metabolic syndrome (MS) (waist circumference, body mass index, blood pressure, triglycerides, HDL-cholesterol and fasting glucose levels) in population from Bosnia and Herzegovina.This study included 43 patients with metabolic syndrome and 43 healthy controls from General Hospital in Tešanj, Bosnia and Herzegovina. Subjects were genotyped for two LPIN1 gene variations (rs11693809: CT and rs2716610: CT) by real time PCR method.In control subjects LPIN1 polymorphism, rs2716610: CT, was significantly associated with a lower body mass index (BMI) (p=0.008) and waist circumference (p=0.008). The second analyzed rs11693809: CT polymorphism was associated with lower blood HbA1c levels (p=0.048) in a group of MS patients.Results of our study suggest that rs2716610: CT polymorphism of LPIN1 gene could have a protective effect against development of metabolic syndrome, while rs11693809: CT might affect a glucose control in patients with MS.