[The concept of tumor-derived exosomes and research progress in bone metastasis of prostate cancer]

Authors :: T S, Zhai
L, Jin
Z, Zhou
X, Liu
J Y, Lu
X D, Yao
L, Ye
Source :: Zhonghua yi xue za zhi. 99(42)
Publication Year :: 2019
Abstract: 外泌体作为一种小囊泡结构负责细胞间通讯工作，几乎可由所有细胞分泌。转移性前列腺癌90%以上部位为骨转移，前列腺癌这种特殊的"亲骨性"涉及到前列腺癌细胞与细胞外基质、血管内皮和骨髓微环境之间的细胞间信号通讯等复杂过程。本文就肿瘤源性外泌体（TDE）作为细胞间通讯工具诱导上皮-间质转化、血管通透性改变及血管生成、转移前微环境形成等以促使前列腺癌骨转移的发生进行了论述。.

Subjects :: Male
Cell Line, Tumor
Humans
Prostatic Neoplasms
Bone Neoplasms
Neoplasm Metastasis
Exosomes

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