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[Two cases of lupus nephritis having a high titer of anti-(histone-DNA) complex antibody without IgG anti-dsDNA antibody]
- Source :
- Rinsho byori. The Japanese journal of clinical pathology. 44(6)
- Publication Year :
- 1996
-
Abstract
- IgG antibody specific to double-stranded DNA (dsDNA) has been recognized as a predictive indicator of the renal involvement in systemic lupus erythematosus. However, we recently experienced two cases of overt lupus nephritis without IgG anti-dsDNA antibody. In both cases, high titers of antibody to the histone dimer (H2A-H2B)-dsDNA complex were detected. They responded well to the corticosteroid therapy, with a cytotoxic agent in one case, and the titers of anti-(histone-DNA) antibody was decreased along with the improvement of proteinuria. Based on the recent reports suggesting a pathogenic role of this antibody in lupus nephritis, we suggest that measurement of the anti-(histone-DNA) antibody is necessary in lupus nephritis patients, especially when IgG anti-dsDNA antibody is not detectable.
Details
- ISSN :
- 00471860
- Volume :
- 44
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Rinsho byori. The Japanese journal of clinical pathology
- Accession number :
- edsair.pmid..........6f6da286d59e951d02443ba2bca6df27