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Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations

Studies of IGF-I and Klotho Protein in Relation to Anabolic-Androgenic Steroid and Growth Hormone Administrations

Authors :
Mikael, Lehtihet
Christina, Stephanou
Annica, Börjesson
Hasanuzzaman, Bhuiyan
Anton, Pohanka
Lena, Ekström
Source :
Frontiers in sports and active living. 4
Publication Year :
2021

Abstract

It has been suggested to longitudinally monitor Insulin-like growth factor I (IGF-I) as a biomarker for the detection of recombinant growth hormone (GH). Subsequently, it is of interest to understand any confounders of endogenous IGF-I. Herein we have studied if serum IGF-I concentration is affected by the intake of anabolic androgenic steroids (AAS) and the potential connection between IGF-I and klotho protein. Moreover, the usefulness of klotho as a biomarker for recombinant GH intake was assessed in healthy male volunteers. An ongoing administration of AAS did not affect the levels of IGF-I. Klotho protein was ~30% higher in men with an ongoing AAS use compared to those with previous (2 months ago) AAS use, and the serum klotho protein correlated negatively with luteinizing hormone (LH) (

Details

ISSN :
26249367
Volume :
4
Database :
OpenAIRE
Journal :
Frontiers in sports and active living
Accession number :
edsair.pmid..........6fc115b0531cb2a0ceab0035c914c57a