Back to Search Start Over

[A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy]

[A Case of Ascending Colon Cancer with Lynch Syndrome Who Underwent XELOX Adjuvant Chemotherapy]

Authors :
Koki, Takase
Kohei, Murata
Yoshinori, Kagawa
Yohei, Nose
Kenji, Kawai
Takuya, Sakamoto
Atsushi, Naito
Kohei, Murakami
Yoshiteru, Katsura
Yoshiaki, Omura
Atsushi, Takeno
Shinichi, Nakatsuka
Yutaka, Takeda
Takeshi, Kato
Shigeyuki, Tamura
Source :
Gan to kagaku ryoho. Cancerchemotherapy. 45(1)
Publication Year :
2018

Abstract

Lynch syndrome is an inherited syndrome with the development of the colorectal and various other cancers. Lynch syndrome is caused by mutations in the mismatch repair genes. A 33 year-old male underwent XELOX adjuvant chemotherapy for ascending colon cancer with Lynch syndrome. Although efficacy of 5-FU is not demonstrated in Lynch syndrome, MOSAIC trial had suggested a benefit from FOLFOX compared with 5-FU in patients who have colorectal cancer with Lynch syndrome. Oxaliplatin-based adjuvant chemotherapy can be a therapeutic option for colorectal cancer in lynch syndrome patients.

Details

ISSN :
03850684
Volume :
45
Issue :
1
Database :
OpenAIRE
Journal :
Gan to kagaku ryoho. Cancerchemotherapy
Accession number :
edsair.pmid..........6fc6b47aa38ab170048504cb2a7aece7