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[Dose and long-term effect of hIGF-1 injection for erectile dysfunction in aged rats]
- Source :
- Zhonghua nan ke xue = National journal of andrology. 14(8)
- Publication Year :
- 2008
-
Abstract
- To investigate the best dose and the long-term effect of the human insulin-like growth factor-1 (hIGF-1) gene injection into the penis of aged rats.Included in this study were 10 young (4 months old) and 40 aged (24 months old) Sprague-Dawley male rats, the latter equally divided into a PBS control and a 10 microg, a 100 microg and a 1 000 microg hIGF-1 injection group. Electrical stimulation was conducted 4 and 8 weeks after hIGF-1 injection into the penile corpus cavernous of the rats to detect the intracavernous pressure (ICP) and mean arterial pressure (MAP). Dose - and time -associated therapeutic results were analyzed and the mRNA expression of hIGF-1 determined by RT - PCR.ICP, MAP and total ICP were significant decreased by electrical stimulation in the aged rats as compared with the young ones (P0.05), statistically increased in the three hIGF-1 dose groups in comparison with the PBS controls (P0.05), and showed no obvious difference between the young rats and the latter two dose groups at 4 and 8 weeks. Although less obvious effect was achieved in the 10 microg group than in the young rats, the therapeutic result was still of significance. The mRNA expression of the hIGF-1 gene was confirmed in all the hIGF-1 treated rats.The hIGF-1 therapy can improve erectile function in aged rats, 100 microg suffices for effective erection and the effect may last at least 8 weeks for a single dose.
Details
- ISSN :
- 10093591
- Volume :
- 14
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Zhonghua nan ke xue = National journal of andrology
- Accession number :
- edsair.pmid..........736d4b66f40ecb233c2335afb827d236