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Ceruloplasmin Deficiency Results in an Anxiety Phenotype Involving Deficits in Hippocampal Iron, Serotonin and BDNF
- Publication Year :
- 2011
-
Abstract
- Ceruloplasmin (Cp) is a ferroxidase involved in iron metabolism by converting Fe2+ to Fe3+, and by regulating cellular iron efflux. In the ceruloplasmin knockout (CpKO) mouse, the deregulation of iron metabolism results in moderate liver and spleen hemosiderosis, but the impact of Cp deficiency on brain neurochemistry and behavior in this animal model is unknown. We found that in contrast to peripheral tissues, iron levels in the hippocampus are significantly reduced in CpKO mice. Although it does not cause any discernable deficits in motor function or learning and memory, Cp deficiency results in heightened anxiety-like behavior in the open field and elevated plus maze tests. This anxiety phenotype is associated with elevated levels of plasma corticosterone. Previous studies provided evidence that anxiety disorders and long-standing stress are associated with reductions in levels of serotonin and brain-derived neurotrophic factor (BDNF) in the hippocampus. We found that levels of serotonin and norepinephrine, and the expression of BDNF and its receptor trkB, are significantly reduced in the hippocampus of CpKO mice. Thus, Cp deficiency causes an anxiety phenotype by a mechanism that involves decreased levels of iron, serotonin, norepinephrine and BDNF in the hippocampus.
- Subjects :
- Male
Serotonin
Transcription, Genetic
Anxiety
Motor Activity
Real-Time Polymerase Chain Reaction
Hippocampus
Article
Mice
Memory
Animals
Learning
Maze Learning
Postural Balance
Brain Chemistry
Mice, Knockout
Brain-Derived Neurotrophic Factor
Ceruloplasmin
Recognition, Psychology
Fear
Iron Deficiencies
Mice, Inbred C57BL
nervous system
Hindlimb Suspension
Corticosterone
Psychomotor Performance
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Accession number :
- edsair.pmid..........737586fb8cf83f7711644004a0f398c4