Back to Search
Start Over
The effect of a promoter polymorphism in the heme oxygenase-1 gene on the risk of ischaemic cerebrovascular events: the influence of other vascular risk factors
- Source :
- Thrombosis research. 113(3-4)
- Publication Year :
- 2003
-
Abstract
- Heme oxygenase-1 (HO-1) has been demonstrated to exert potent anti-oxidant and anti-inflammatory effects in the context of atherosclerotic vascular disease, and therefore was referred to as a potential vascular protective factor. A (GT)n dinucleotide repeat polymorphism in the HO-1 promoter has been shown to modulate HO-1 gene expression. Short (25) GT repeats were associated with HO-1 up-regulation, and therefore may influence susceptibility to ischaemic vascular events. We investigated the association of HO-1 repeat length with the risk of cerebrovascular events in a case control study and assessed possible interrelations with vascular risk factors. We determined the number of GT repeats in the HO-1 promoter in 399 patients with ischaemic cerebrovascular events and 398 healthy controls and compared the frequencies of short (25) repeat (class S) and long (or =25) repeat (class L) alleles after adjustment for potentially confounding factors. Genotype distributions of S/S, S/L and L/L in patients were 9.8% (n=39), 45.1% (n=180) and 45.1% (n=180), which was similar to the distribution in controls with 11.5% (n=46), 44.5% (n=177) and 44.0% (n=175). In the presence of vascular risk factors, the HO-1 genotype became functionally relevant: in patients without hyperlipidemia the S/S genotype exerted a protective effect on the development of ischaemic cerebrovascular events (OR 0.2; 95% CI 0.1-0.6), while this effect was no longer present in hyperlipidemic patients. Short (25 GT) repeats in the HO-1 gene promoter confer a reduced risk for cerebrovascular events in individuals with normal plasma lipid levels. This may explain controversial findings in different populations.
- Subjects :
- Adult
Male
Polymorphism, Genetic
Genetic Variation
Membrane Proteins
Minisatellite Repeats
Middle Aged
Stroke
Gene Frequency
Risk Factors
Case-Control Studies
Heme Oxygenase (Decyclizing)
Humans
Female
Promoter Regions, Genetic
Alleles
Heme Oxygenase-1
Aged
Microsatellite Repeats
Retrospective Studies
Subjects
Details
- ISSN :
- 00493848
- Volume :
- 113
- Issue :
- 3-4
- Database :
- OpenAIRE
- Journal :
- Thrombosis research
- Accession number :
- edsair.pmid..........73fc5cf78abe4c512a12ce868bb211eb