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Full-term pregnancy with embryos from donated oocytes in a 36-year-old woman allografted for chronic myeloid leukemia

Authors :
B, Rio
H, Letur-Könirsch
F, Ajchenbaum-Cymbalista
F, Bauduer
D, De Ziegler
C, Pelissier
A, Bernadou
R, Frydman
R, Zittoun
Source :
Bone marrow transplantation. 13(4)
Publication Year :
1994

Abstract

We report the first case of full-term pregnancy arising from donated oocytes in a 36-year-old woman with chronic myeloid leukemia (CML), 6 years after allogeneic bone marrow transplantation (BMT) following total body irradiation (TBI) (12 Gy) and cyclophosphamide 120 mg/kg. The first attempt at implantation with her own cryopreserved ovocytes was unsuccessful. Thereafter, she became pregnant after donated oocyte implantation using estradiol and progesterone support replacing the defective ovarian function. The baby was normal. Unfortunately, 6 months later, she relapsed in chronic phase of CML.

Details

ISSN :
02683369
Volume :
13
Issue :
4
Database :
OpenAIRE
Journal :
Bone marrow transplantation
Accession number :
edsair.pmid..........79882fb903e24fa1f897ce50b0a261c1