Synthesis and antidepressant-like activity of novel aralkyl piperazine derivatives targeting SSRI/5-HT

Authors :: Zheng-Song, Gu
Ai-Nan, Zhou
Ying, Xiao
Qing-Wei, Zhang
Jian-Qi, Li
Source :: European journal of medicinal chemistry. 144
Publication Year :: 2017
Abstract: A series of novel aralkyl piperazine derivatives were synthesized, and evaluated for their serotonin reuptake inhibitory and 5-HT

Subjects :: Male
Dose-Response Relationship, Drug
Molecular Structure
Antidepressive Agents
Piperazines
Rats
Rats, Sprague-Dawley
Structure-Activity Relationship
Receptors, Serotonin
Receptor, Serotonin, 5-HT1A
Animals
Humans
Piperazine
Selective Serotonin Reuptake Inhibitors

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