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Authors :
Lara, Davani
Xiaoqing, Fu
Angela, De Simone
Peng, Li
Serena, Montanari
Michael, Lämmerhofer
Vincenza, Andrisano
Source :
Journal of pharmaceutical and biomedical analysis. 219
Publication Year :
2022

Abstract

Currently Alzheimer's Disease (AD) pathological pathways, which lead to cell death and dementia, are not completely well-defined; in particular, the lipid changes in brain tissues that begin years before AD symptoms. Due to the central role of the amyloid aggregation process in the early phase of AD pathogenesis, we aimed at developing a lipidomic approach to evaluate the amyloid toxic effects on differentiated human neuroblastoma derived SH-SY5Y cells. First of all, this work was performed to highlight qualitative and relative quantitative lipid variations in connection with amyloid toxicity. Then, with an open outcome, the study was focused to find out some new lipid-based biomarkers that could result from the interaction of amyloid peptide with cell membrane and could justify neuroblastoma cells neurotoxicity. Hence, cells were treated with increasing concentration of Aβ

Details

ISSN :
1873264X
Volume :
219
Database :
OpenAIRE
Journal :
Journal of pharmaceutical and biomedical analysis
Accession number :
edsair.pmid..........7b0c49bb8d6106b409b0795efc7f6bec