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Immune system, cell senescence, aging and longevity--inflamm-aging reappraised
- Source :
- Current pharmaceutical design. 19(9)
- Publication Year :
- 2013
-
Abstract
- Inflamm-aging, that is the age-associated inflammatory status, is considered one of the most striking consequences of immunosenescence, as it is believed to be linked to the majority of age-associated diseases sharing an inflammatory basis. Nevertheless, evidence is emerging that inflamm-aging is at least in part independent from immunological stimuli. Moreover, centenarians who avoided or delayed major inflammatory diseases display markers of inflammation. In this paper we proposed a reappraisal of the concept of inflamm-aging, suggesting that its pathological effects can be independent from the total amount of pro-inflammatory mediators, but they would be rather associated with the anatomical district and type of cells where they are produced and where they primarily act.
- Subjects :
- Inflammation
Aging
Immune System
Longevity
Humans
Apoptosis
DNA
Cellular Senescence
Subjects
Details
- ISSN :
- 18734286
- Volume :
- 19
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Current pharmaceutical design
- Accession number :
- edsair.pmid..........7efd856df241d0d62276a73a56faabce