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'Selective' Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu
- Source :
- Molecular pharmacology. 93(5)
- Publication Year :
- 2017
-
Abstract
- Numerous positive and negative allosteric modulators (PAMs and NAMs) of class C G protein-coupled receptors (GPCRs) have been developed as valuable preclinical pharmacologic tools and therapeutic agents. Although many class C GPCR allosteric modulators have undergone subtype selectivity screening, most assay paradigms have failed to perform rigorous pharmacologic assessment. Using mGlu
Details
- ISSN :
- 15210111
- Volume :
- 93
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Molecular pharmacology
- Accession number :
- edsair.pmid..........7fa5191363d7ffa355fdfd382c7ec675