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Exceedingly fast copper(II)-promoted ortho C-H trifluoromethylation of arenes using TMSCF₃
- Source :
- Angewandte Chemie (International ed. in English). 53(39)
- Publication Year :
- 2014
-
Abstract
- The direct ortho-trifluoromethylation of arenes, including heteroarenes, with TMSCF3 has been accomplished by a copper(II)-promoted C-H activation reaction which completes within 30 minutes. Mechanistic investigations are consistent with the involvement of C-H activation, rather than a simple electrophilic aromatic substitution (SE Ar), as the key step.
Details
- ISSN :
- 15213773
- Volume :
- 53
- Issue :
- 39
- Database :
- OpenAIRE
- Journal :
- Angewandte Chemie (International ed. in English)
- Accession number :
- edsair.pmid..........84b48d81c3c6b0f73203d111d750d301