Zinc Inhibits Cadherin 1 Expression Induced by 1α,25-Dihydroxyvitamin D

Zinc is a mineral that is essential for biological molecules, such as transcription factors, and is involved in the maintenance of intestinal homeostasis. Vitamin D signaling is mediated by vitamin D receptor (VDR) activated by 1α,25-dihydroxyvitamin DColon cancer SW480 and HCT116 cells were treated with zinc chloride (ZnClTreatment of cells with ZnClZinc signaling suppresses VDR-induced expression of CDH1.