Back to Search Start Over

Correction to: Treatment of myeloid malignancies relapsing after allogeneic hematopoietic stem cell transplantation with venetoclax and hypomethylating agents—a retrospective multicenter analysis on behalf of the German Cooperative Transplant Study Group

Authors :
Schuler, Esther
Wagner-Drouet, Eva-Maria
Ajib, Salem
Bug, Gesine
Crysandt, Martina
Dressler, Sabine
Hausmann, Andreas
Heidenreich, Daniela
Hirschbühl, Klaus
Hoepting, Matthias
Jost, Edgar
Kaivers, Jennifer
Klein, Stefan
Koldehoff, Michael
Kordelas, Lambros
Kriege, Oliver
Müller, Lutz P.
Rautenberg, Christina
Schaffrath, Judith
Schmid, Christoph
Wolff, Daniel
Haas, Rainer
Bornhäuser, Martin
Schroeder, Thomas
Kobbe, Guido
Source :
Ann Hematol
Publication Year :
2021
Publisher :
Springer Berlin Heidelberg, 2021.

Abstract

Treatment of relapse after allogeneic hematopoietic stem cell transplantation (alloHSCT) remains a great challenge. Aiming to evaluate the combination of venetoclax and hypomethylating agents (HMAClax) for the treatment of relapse of myeloid malignancies after alloHSCT, we retrospectively collected data from 32 patients treated at 11 German centers. Venetoclax was applied with azacitidine (n = 13) or decitabine (n = 19); 11 patients received DLI in addition. HMAClax was the first salvage therapy in 8 patients. The median number of cycles per patient was 2 (1-19). All but 1 patient had grade 3/4 neutropenia. Hospital admission for grade 3/4 infections was necessary in 23 patients (72%); 5 of these were fatal. In 30 evaluable patients, overall response rate (ORR) was 47% (14/30, 3 CR MRD

Details

Language :
English
Database :
OpenAIRE
Journal :
Ann Hematol
Accession number :
edsair.pmid..........878dc598c1b7e40188e2a5a1b33cf2a6