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Renal Injuries in Primary Aldosteronism (PA) ~Quantitative Histopathological Analysis of 19 PA patients~

Renal Injuries in Primary Aldosteronism (PA) ~Quantitative Histopathological Analysis of 19 PA patients~

Authors :
Ogata, Hiroko
Yamazaki, Yuto
Tezuka, Yuta
Gao, Xin
Omata, Kei
Ono, Yoshikiyo
Kawasaki, Yoshihide
Tanaka, Tomoaki
Nagano, Hidekazu
Wada, Norio
Oki, Yutaka
Ikeya, Akira
Oki, Kenji
Takeda, Yoshiyu
Kometani, Mitsuhiro
Kageyama, Kazunori
Terui, Ken
Gomez-Sanchez, Celso E.
Liu, Shujun
Morimoto, Ryo
Joh, Kensuke
Sato, Hiroshi
Miyazaki, Mariko
Ito, Akihiro
Arai, Yoichi
Nakamura, Yasuhiro
Ito, Sadayoshi
Satoh, Fumitoshi
Sasano, Hironobu
Source :
Hypertension
Publication Year :
2021

Abstract

The rapid progression of chronic kidney disease and higher incidence of cardiovascular complications are well known in hyperaldosteronism patients. However, detailed renal histopathological characteristics of this disease have remained unknown. Therefore, renal biopsy specimens of 19 cases with unilateral hyperaldosteronism were compared with 22 autopsy renal cases of estimated glomerular filtration rate-matched essential hypertension without nephropathy or endocrine disorders to explore the hyperaldosteronism- specific histopathological renal changes in this study. Global and segmental glomerulosclerosis, interstitial fibrosis, infiltration of inflammatory cells, arteriosclerosis, hyalinization of arterioles and immunoreactivity of mineralocorticoid receptor, 11β-hydroxysteroid dehydrogenase type 1 and 2 and renin were all quantitatively evaluated. The ultrastructural analysis was added in 3 hyperaldosteronism cases. Both mineralocorticoid receptor (p

Details

Language :
English
Database :
OpenAIRE
Journal :
Hypertension
Accession number :
edsair.pmid..........8888bb93e9911a7240c7295da1efd092