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Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics
- Source :
- Translational psychiatry. 12(1)
- Publication Year :
- 2021
-
Abstract
- Despite 50+ years of drug discovery, current antipsychotics have limited efficacy against negative and cognitive symptoms of schizophrenia, and are ineffective-with the exception of clozapine-against any symptom domain for patients who are treatment resistant. Novel therapeutics with diverse non-dopamine D
- Subjects :
- Dopamine
Drug Discovery
Schizophrenia
Humans
Clozapine
Antipsychotic Agents
Subjects
Details
- ISSN :
- 21583188
- Volume :
- 12
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Translational psychiatry
- Accession number :
- edsair.pmid..........8a8ad3cf909c360dcebe299ae837189e