Back to Search Start Over

Extracellular Matrix Stiffness Exists in a Feedback Loop that Drives Tumor Progression

Authors :
Allison K, Simi
Mei-Fong, Pang
Celeste M, Nelson
Source :
Advances in experimental medicine and biology. 1092
Publication Year :
2018

Abstract

Cells communicate constantly with their surrounding extracellular matrix (ECM) to maintain homeostasis, using both mechanical and chemical signals. In cancer, abnormal signaling leads to stiffening of the ECM. A stiff microenvironment affects many aspects of the cell, including internal molecular signaling as well as behaviors such as motility and proliferation. Thus, cells and ECM interact in a feedback loop to drive matrix deposition and cross-linking, which alter the mechanical properties of the tissue. Stiffer tissue enhances the invasive potential of a tumor and decreases therapeutic efficacy. This chapter describes how specific molecular effects caused by an abnormally stiff tissue drive macroscopic changes that help determine disease outcome. A complete understanding may foster the generation of new cancer therapies.

Details

ISSN :
00652598
Volume :
1092
Database :
OpenAIRE
Journal :
Advances in experimental medicine and biology
Accession number :
edsair.pmid..........8d99cd9e0499427f04f89d519411abd0