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Immunogenicity study to investigate the interchangeability among three different types of polio vaccine
- Source :
- Medicine
- Publication Year :
- 2017
- Publisher :
- Wolters Kluwer Health, 2017.
-
Abstract
- In Japan, the routine immunization program with oral polio vaccine (OPV) has been suspended since September 2012, when a program with 4 doses of inactivated monovalent polio vaccine (IPV) or quadrivalent vaccine against diphtheria, pertussis, and tetanus with IPV (DTaP-IPV) was introduced. The aim of this study was to examine the interchangeability among these 3 types of polio vaccines. We conducted a prospective cohort study at 5 pediatric clinics in Japan. A total of 153 infants were assigned to 1 of the 4 groups by considering the vaccination history of OPV and trivalent vaccine against DTaP. Eleven infants with a history of OPV received 3 doses of DTaP-IPV; 49 infants with a history of OPV and DTaP received 3 doses of IPV; 50 polio vaccine-naïve infants received 2 doses of IPV followed by 2 doses of DTaP-IPV; and 43 polio vaccine-naive infants received 2 doses of DTaP-IPV followed by IPV. The immunogenicity after polio vaccination was evaluated among these 4 groups. After 2 doses of polio vaccination, more than 80% of the infants exhibited a neutralization antibody titer ≥1:8 for all Sabin strains and wild strains in all groups. After the third dose, the seroprotection proportion (i.e., a neutralization antibody titer ≥1:8) reached about 100%. After the fourth dose, a neutralization antibody titer exceeded the required protective levels (i.e., a neutralization antibody titer ≥1:8) considerably in all groups. Four doses of polio vaccines induced a sufficient level of immunity in Japanese infants, irrespective of vaccine combinations or order.
- Subjects :
- safety
Male
infants
Dose-Response Relationship, Immunologic
Observational Study
Infant
Antibodies, Viral
complex mixtures
immune response
Poliovirus
Poliovirus Vaccine, Inactivated
Immunogenicity, Vaccine
Japan
polio vaccine
Child, Preschool
Poliovirus Vaccine, Oral
Humans
Female
Prospective Studies
Child
interchangeability
Diphtheria-Tetanus-Pertussis Vaccine
Research Article
Subjects
Details
- Language :
- English
- ISSN :
- 15365964 and 00257974
- Volume :
- 96
- Issue :
- 23
- Database :
- OpenAIRE
- Journal :
- Medicine
- Accession number :
- edsair.pmid..........91ce660a573827a83f16fc044cd3efc4