Control of blood glucose and diabetic vascular disease

The definite demonstration that the microvascular complications of diabetes can be prevented by the normalization of blood glucose concentrations in man cannot be made since normoglycaemic cannot be sustained from the beginning of the disease with our current methods of treatment. Clinical studies despite their difficulties and limits seem to support the hypothesis that good control of diabetes at least in terms blood glucose is worthwhile. Some prominent scientists and physicians have questionned the validity of clinical studies and findings in animals and have asked whether the benefits of tight control have been sufficiently proven to warrant the risks of hypoglycaemia. Different groups of arguments have been given to support this point of view. The final answer to the question of whether blood sugar control prevents the complications of diabetes will probably come from the development of a technique for achieving perfect control of blood sugar for example with transplantation or an artificial pancreas.