Design, synthesis, and biological evaluation of pyrazole derivatives containing acetamide bond as potential BRAF

Authors :: Chen-Ru, Wang
Ze-Feng, Wang
Lu, Shi
Zhong-Chang, Wang
Hai-Liang, Zhu
Source :: Bioorganicmedicinal chemistry letters. 28(14)
Publication Year :: 2018
Abstract: With the increasingly acquired resistance, relapse and side effects of known marketed BRAF

Subjects :: Models, Molecular
Proto-Oncogene Proteins B-raf
Structure-Activity Relationship
Dose-Response Relationship, Drug
Molecular Structure
Cell Line, Tumor
Drug Design
Acetamides
Humans
Pyrazoles
Drug Screening Assays, Antitumor
HT29 Cells
Cell Proliferation

Tools