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Cembranoid-Related Metabolites and Biological Activities from the Soft Coral
- Source :
- Marine Drugs
- Publication Year :
- 2018
-
Abstract
- Five new cembranoid-related diterpenoids, namely, flexibilisins D and E (1 and 2), secoflexibilisolides A and B (3 and 4), and flexibilisolide H (5), along with nine known compounds (6–14), were isolated from the soft coral Sinularia flexibilis. Their structures were established by extensive spectral analysis. Compound 3 possesses an unusual skeleton that could be biogenetically derived from cembranoids. The cytotoxicity and anti-inflammatory activities of the isolates were investigated, and the results showed that dehydrosinulariolide (7) and 11-epi-sinulariolide acetate (8) exhibited cytotoxicity toward a limited panel of cancer cell lines and 14-deoxycrassin (9) displayed anti-inflammatory activity by inhibition of superoxide anion generation and elastase release in N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced human neutrophils.
- Subjects :
- Pancreatic Elastase
Cytochalasin B
Neutrophils
Anti-Inflammatory Agents
cembranoid-related compounds
Antineoplastic Agents
Anthozoa
Article
N-Formylmethionine Leucyl-Phenylalanine
Superoxides
Sinularia flexibilis
Cell Line, Tumor
secoflexibilisolide
Animals
Humans
Diterpenes
Drug Screening Assays, Antitumor
flexibilisin
flexibilisolide
Subjects
Details
- ISSN :
- 16603397
- Volume :
- 16
- Issue :
- 8
- Database :
- OpenAIRE
- Journal :
- Marine drugs
- Accession number :
- edsair.pmid..........9a229b5f682d4369627ea73153fb246e