Open four-compartment model in the measurement of liver perfusion

The goal was to improve informativeness in the determination of liver perfusion with a clinically available iodinated computed tomography (CT) contrast agent by developing open multicompartmental modeling.Contrast-enhanced functional CT (fCT) examinations were conducted with temporal resolutions of 200-500 msec to 6 New Zealand White rabbits. First, we applied conventional open two-compartment model for the determination of arterial and portal blood flows (FA and FP), blood and interstitial volume fractions (fb and fi), and capillary permeability-surface area product (PS) of liver parenchyma. Then, we improved the modeling of vascular physiology by developing three- and open four-compartment models. For comparison, conventional single-compartment model was applied. We determined FA and FP also by using the peak-gradient method.Conventional two-compartment model yielded identical fittings with single-compartment model and does not provide unique solutions for fb and fi. The presented open four-compartment model provided FA and FP values of 0.40 +/- 0.19 and 1.99 +/- 0.57 mL/min/mL (tissue), fb and fi values of 0.30 +/- 0.05 and 0.19 +/- 0.04 mL/mL (tissue), and PS values of 4.0 +/- 1.7 mL/min/mL (tissue). FA and FP are in a good agreement with those derived by using the peak-gradient method.With the use of clinical extracellular iodinated CT contrast agent, the presented open four-compartment model provided physiological arterial and portal blood flow values and is also a potential tool in the assessment of blood and interstitial volume fractions and capillary permeability-surface area product. Moreover, the model requires neither measurements from hepatic vein or from other organs nor visual determination of arterial or portal phase.