Back to Search
Start Over
Neurodevelopmental outcome at 2 years of corrected age in fetuses with increased nuchal translucency thickness and normal karyotype compared with matched controls
- Source :
- Ultrasound in Obstetrics & Gynecology
- Publication Year :
- 2021
- Publisher :
- John Wiley & Sons, Ltd., 2021.
-
Abstract
- Objectives Increased nuchal translucency (NT) thickness is an antenatal marker of aneuploidy or malformation that can lead to termination of pregnancy. This study assessed the long‐term neurodevelopmental prognosis of infants who had isolated increased NT in utero. Methods This was a prospective cohort study of infants with a NT thickness > 95th percentile in the first trimester, but with a normal karyotype and no major anomalies, and controls with normal NT matched for birth weight, Apgar score, place of birth, parity and gestational age at birth. At 2 years of corrected age, all infants underwent the psychometric Brunet–Lézine test to evaluate their developmental quotient (DQ), overall (global) and specifically for the areas of posture, language, coordination and sociability. Results A total of 203 chromosomally normal infants were included in the increased‐NT group and 208 in the control group. The mean global DQ was significantly lower in the increased‐NT group than in the control group (108.6 ± 9.7 vs 112.8 ± 8.3; P 5 mm in 11%, with a mean global DQ of 108.4, 110.1 and 109.7, respectively. Conclusions Infants who had isolated increased fetal NT in the first trimester had a significantly lower, but normal, DQ at a corrected age of 2 years, when compared with controls. The findings were independent of the infant's sex, fetal NT thickness and the mother's educational level. © 2020 Authors. Ultrasound in Obstetrics & Gynecology published by John Wiley & Sons Ltd on behalf of International Society of Ultrasound in Obstetrics and Gynecology.
- Subjects :
- sonography
Adult
Male
Original Paper
prenatal diagnosis
neurodevelopmental disorders
screening
Karyotype
Infant, Newborn
Infant
Mental Status and Dementia Tests
Original Papers
ultrasonographic prenatal diagnosis
Pregnancy Trimester, First
Fetus
Pregnancy
Case-Control Studies
Child, Preschool
Prevalence
Humans
Female
Prospective Studies
Nuchal Translucency Measurement
outcome assessment
Subjects
Details
- Language :
- English
- ISSN :
- 14690705 and 09607692
- Volume :
- 57
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Ultrasound in Obstetrics & Gynecology
- Accession number :
- edsair.pmid..........a341d330522226c140edc1a9036a4954