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The proneural wave in the

The proneural wave in the

Authors :
David J, Jörg
Elizabeth E, Caygill
Anna E, Hakes
Esteban G, Contreras
Andrea H, Brand
Benjamin D, Simons
Source :
eLife
Publication Year :
2018

Abstract

In living organisms, self-organised waves of signalling activity propagate spatiotemporal information within tissues. During the development of the largest component of the visual processing centre of the Drosophila brain, a travelling wave of proneural gene expression initiates neurogenesis in the larval optic lobe primordium and drives the sequential transition of neuroepithelial cells into neuroblasts. Here, we propose that this ‘proneural wave’ is driven by an excitable reaction-diffusion system involving epidermal growth factor receptor (EGFR) signalling interacting with the proneural gene l’sc. Within this framework, a propagating transition zone emerges from molecular feedback and diffusion. Ectopic activation of EGFR signalling in clones within the neuroepithelium demonstrates that a transition wave can be excited anywhere in the tissue by inducing signalling activity, consistent with a key prediction of the model. Our model illuminates the physical and molecular underpinnings of proneural wave progression and suggests a generic mechanism for regulating the sequential differentiation of tissues.

Details

ISSN :
2050084X
Volume :
8
Database :
OpenAIRE
Journal :
eLife
Accession number :
edsair.pmid..........a87ff8dd9b6f84142e63b943462b506b