Discovery of morpholine-based aryl sulfonamides as Na

Authors :: Yong-Jin, Wu
Jason, Guernon
Andrea, McClure
Brian, Venables
Ramkumar, Rajamani
Kevin J, Robbins
Ronald J, Knox
Michele, Matchett
Rick L, Pieschl
James, Herrington
Linda J, Bristow
Nicholas A, Meanwell
Richard, Olson
Lorin A, Thompson
Carolyn, Dzierba
Source :: Bioorganicmedicinal chemistry letters. 28(5)
Publication Year :: 2017
Abstract: Replacement of the piperidine ring in the lead benzenesulfonamide Na

Subjects :: Voltage-Gated Sodium Channel Blockers
Structure-Activity Relationship
Sulfonamides
Dose-Response Relationship, Drug
Molecular Structure
Morpholines
NAV1.7 Voltage-Gated Sodium Channel
Humans

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