Discovery and optimization of a novel CNS penetrant series of mGlu

Authors :: Caitlin N, Kent
Mark G, Fulton
Kaylee J, Stillwell
Jonathan W, Dickerson
Matthew T, Loch
Alice L, Rodriguez
Anna L, Blobaum
Olivier, Boutaud
Jerri L, Rook
Colleen M, Niswender
P Jeffrey, Conn
Craig W, Lindsley
Source :: Bioorganicmedicinal chemistry letters. 37
Publication Year :: 2021
Abstract: A high throughput screen (HTS) identified a novel, but weak (EC

Subjects :: Catalepsy
Disease Models, Animal
Mice
Structure-Activity Relationship
Neuroprotective Agents
Allosteric Regulation
Dose-Response Relationship, Drug
Molecular Structure
Drug Discovery
Animals
Haloperidol
Parkinson Disease
Receptors, Metabotropic Glutamate

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