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Nizatidine ameliorates gastroparesis in Parkinson's disease: a pilot study
- Source :
- Movement disorders : official journal of the Movement Disorder Society. 29(4)
- Publication Year :
- 2013
-
Abstract
- The objective of this work was to perform an open trial of the effects of nizatidine (NZT), a selective histamine H2-receptor antagonist and a cholinomimetic, on gastroparesis in Parkinson's disease (PD) patients, using objective parameters given by a gastric emptying study using a (13) C-sodium acetate expiration breath test.Twenty patients with PD were enrolled in the study. There were 13 men and 7 women; aged 68.0 ± 7.72 years; disease duration 5.50 ± 3.62 years. All patients underwent the breath test and a gastrointestinal questionnaire before and after 3 months of administration of NZT at 300 mg/day. Statistical analysis was performed by Student t test.NZT was well tolerated by all patients and none had abdominal pain or other adverse effects. NZT significantly shortened Tmax ((13) C) (the peak time of the (13) C-dose-excess curve) (P 0.05).Although this is a pilot study, we found a significant shortening of gastric emptying time after administration of NZT in PD patients.
Details
- ISSN :
- 15318257
- Volume :
- 29
- Issue :
- 4
- Database :
- OpenAIRE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Accession number :
- edsair.pmid..........adf9bb69607bfd58dfdeab72803df7ea