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Efficacy and Safety of Dabrafenib in Pediatric Patients with
- Source :
- Clinical cancer research : an official journal of the American Association for Cancer Research. 25(24)
- Publication Year :
- 2019
-
Abstract
- Pediatric low-grade glioma (pLGG) is the most prevalent childhood brain tumor. Patients withPatients ages 1 to18 years who hadOverall, 32 patients with pLGG were enrolled (part 1,Dabrafenib demonstrated meaningful clinical activity and acceptable tolerability in patients with
- Subjects :
- Male
Proto-Oncogene Proteins B-raf
Adolescent
Maximum Tolerated Dose
Brain Neoplasms
Imidazoles
Infant
Glioma
Progression-Free Survival
Treatment Outcome
Drug Resistance, Neoplasm
Child, Preschool
Oximes
Humans
Female
Tissue Distribution
Patient Safety
Neoplasm Grading
Neoplasm Recurrence, Local
Child
Protein Kinase Inhibitors
Subjects
Details
- ISSN :
- 15573265
- Volume :
- 25
- Issue :
- 24
- Database :
- OpenAIRE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Accession number :
- edsair.pmid..........b329a0e9530740fa63f4d68019ed4154