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[Neurological manifestations of vasculitis and primary central nervous system vasculitis]
- Source :
- Zeitschrift fur Rheumatologie. 71(7)
- Publication Year :
- 2012
-
Abstract
- Neurologic complications of vasculitis occur frequently in the form of either peripheral neuropathy or manifestations within the central nervous system (CNS). Primary vasculitis of the CNS is characterized by central nervous system manifestations only with no evidence of systemic disease manifestations. Large vessel vasculitis is particularly associated with central nervous system complications, such as ischemic cerebral infarcts whereas medium size, e.g. polyarteritis nodosa and small vessel vasculitis, e.g. antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis manifest with peripheral neuropathies and central nervous system complications. The same also holds true for Behçet's disease which affects both large, medium and small sized arteries and veins. Due to the severity of nervous system manifestations a highly potent immunosuppressive therapy (e.g. cyclophosphamide and glucocorticoids) is usually required for remission induction. Virus-associated vasculitis (e.g. hepatitis C-associated cryoglobulinemic vasculitis) should receive antiviral therapy as first line treatment. Chronic damage is frequent in spite of swift initiation of immunosuppressive treatment.
Details
- Language :
- German
- ISSN :
- 14351250
- Volume :
- 71
- Issue :
- 7
- Database :
- OpenAIRE
- Journal :
- Zeitschrift fur Rheumatologie
- Accession number :
- edsair.pmid..........b4677bfb53e30bf6dc123d10634d4e6d