HRS phosphorylation drives immunosuppressive exosome secretion and restricts CD8

Authors :: Lei, Guan
Bin, Wu
Ting, Li
Lynn A, Beer
Gaurav, Sharma
Mingyue, Li
Chin Nien, Lee
Shujing, Liu
Changsong, Yang
Lili, Huang
Dennie T, Frederick
Genevieve M, Boland
Guangcan, Shao
Tatyana M, Svitkina
Kathy Q, Cai
Fangping, Chen
Meng-Qiu, Dong
Gordon B, Mills
Lynn M, Schuchter
Giorgos C, Karakousis
Tara C, Mitchell
Keith T, Flaherty
David W, Speicher
Youhai H, Chen
Meenhard, Herlyn
Ravi K, Amaravadi
Xiaowei, Xu
Wei, Guo
Source :: Nature communications. 13(1)
Publication Year :: 2021
Abstract: The lack of tumor infiltration by CD8

Subjects :: Mice
Cell Line, Tumor
Programmed Cell Death 1 Receptor
Tumor Microenvironment
Animals
Humans
Immunotherapy
CD8-Positive T-Lymphocytes
Phosphorylation
Exosomes
Melanoma
B7-H1 Antigen

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