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[Effect of total flavones from Cuscuta chinensis on expression of Fas/FasL, PCNA and HB-EGF in SD rats model with bromocriptine-induced abortion]
- Source :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials. 31(11)
- Publication Year :
- 2009
-
Abstract
- To explore the effect of total flavones from cuscuta chinensis (TFCC) on expression of Fas, PCNA and HB-EGF in SD rats model with bromocriptine-induced abortion.The model rats of bromocriptine during 6-8 d of pregnancy induced early abortion was established, adopting respectively herbs in high and low dosage and progesterone affect model rat and after 12 d, Immunohistochemical was applied to determine Fas, HB-EGF and PCNA in deciduas and placenta.Expression of PCNA on trophoblast and deciduas, HB-EGF on trophoblast, PR on deciduas in the model used Semen cuscutae flavonoid, proesterone and normal pregnacy, were significantlly higher than those of the pure model. Expression of Fas on trophoblast and deciduas in above four groups, were significantlly lower than those of the pure model. There were no expression of HB-EGF on deciduas.TFCC regulates the proliferation and apoptosis of the deciduas and cytotrophoblasts and prevents spontaneous abortions.
- Subjects :
- Male
Fas Ligand Protein
Plants, Medicinal
Placenta
Apoptosis
Cuscuta
Flavones
Immunohistochemistry
Rats
Abortion, Spontaneous
Rats, Sprague-Dawley
Random Allocation
Pregnancy
Proliferating Cell Nuclear Antigen
Decidua
Animals
Intercellular Signaling Peptides and Proteins
Female
fas Receptor
Bromocriptine
Heparin-binding EGF-like Growth Factor
Subjects
Details
- ISSN :
- 10014454
- Volume :
- 31
- Issue :
- 11
- Database :
- OpenAIRE
- Journal :
- Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials
- Accession number :
- edsair.pmid..........b87b119bd4225341f0c31dba54ab2b86