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Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study

Association between Low-density Lipoprotein Receptor-related Protein 5 Polymorphisms and Type 2 Diabetes Mellitus in Han Chinese: a Case-control Study

Authors :
Hai Fei, You
Jing Zhi, Zhao
Yu Jia, Zhai
Lei, Yin
Chao, Pang
Xin Ping, Luo
Ming, Zhang
Jin Jin, Wang
Lin Lin, Li
Yan, Wang
Qian, Wang
Bing Yuan, Wang
Yong Cheng, Ren
Dong Sheng, Hu
Source :
Biomedical and environmental sciences : BES. 28(7)
Publication Year :
2014

Abstract

To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs). Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to describe the strength of the association by logistic regression.In the study subjects, neither rs12363572 nor rs4930588 was significantly associated with T2DM, even after adjusting for relevant covariates. When stratified by body mass index (BMI), the two SNPs were also not associated with T2DM. Among the 3 common haplotypes, only haplotype TT was associated with reduced risk of T2DM (OR 0.820, 95% CI 0.732-0.919). In addition, rs12363572 was associated with BMI (P0.001) and rs4930588 was associated with triglyceride levels (P=0.043) in 507 newly diagnosed T2DM cases but not in healthy controls.No LRP5 variant was found to be associated with T2DM in Han Chinese, but haplotype TT was found to be associated with T2DM.

Details

ISSN :
08953988
Volume :
28
Issue :
7
Database :
OpenAIRE
Journal :
Biomedical and environmental sciences : BES
Accession number :
edsair.pmid..........b889aca4ccf1b76c40d1e5207112eeeb