Analysis of the activation of the Nrf2-ARE pathway following optic nerve injury in mice

The Nrf2-ARE pathway plays a cytoprotective role in many tissues,but its protective function in the optic nerve is unclear. The purpose of the study is to investigate the changes in activation of the Nrf2-ARE pathway following optic nerve injury (ONI) in mice.Using ONI mice models, the expression levels of Nrf2 in optic nerves were determined by real-time PCR at various time points.The expression of Nrf2mRNA was significantly upregulated at 1 d after ONI, peaking at 30 min after ONI.The Nrf2-ARE pathway was activated after ONI, providing evidence for the study of the protection and underlying mechanism of Nrf2-ARE pathway on optic nerves.